Endocrine Abstracts

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant genetic disorder characterized by parathyroid adenomas, enteropancreatic endocrine tumors and anterior pituitary adenomas. It is caused by inactivating mutations of the MEN1 tumor suppressor gene, encoding menin (chromosome 11q13). A large family with several members affected were evaluated for clinical and genetic characteristic of MEN1.The index male patient (42 yr) presented ...